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Using English Wiktionary XML Dump dated Feb 4th 2009
Using WordNet 3.0
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operate
  • (verb)
    1. To perform a work or labor; to exert power or strength, physical or mechanical; to act.
    2. To produce an appropriate physical effect; to issue in the result designed by nature; especially (Med.), to take appropriate effect on the human system.
    3. To act or produce effect on the mind; to exert moral power or influence.
    4. To perform some manual act upon a human body in a methodical manner, and usually with instruments, with a view to restore soundness or health, as in amputation, lithotomy, etc.
    5. To deal in stocks or any commodity with a view to speculative profits.
    6. To produce, as an effect; to cause.
    7. To put into, or to continue in, operation or activity; to work; as, to operate a machine.